Key words: atrial fibrillation mapping goat anti-arrhythmic drugs
Abstract: Objective: In the goat persistent atrial fibrillation (AF) model of class Ic antiarrhythmic drug cibenzoline on atrial epicardial unipolar electrogram morphology . METHODS: In 7
goats were atrial suture 83 outer membrane electrode. stimulator with automatic maintenance of atrial fibrillation, atrial fibrillation to be sustained for 4 weeks after intravenous infusion of cibenzoline [0.1 mg / ( kg • min)]
, until the termination of atrial fibrillation. recorded after treatment of atrial fibrillation circumference (AFCL) change of AFCL were extended by 20, 40, 60, 80 ms, and the 16 before cardioversion of atrial fibrillation s
the period between the atrial potential in various parts of the percentage of abnormal and left atrial conduction velocity. Results: In the intravenous infusion of cibenzoline, the mean AFCL
gradually extended gradually decreased atrial conduction velocity, abnormal potential percentage gradually reduced compared with before infusion were significantly different (P all <0.05). Conclusion: Ic
class antiarrhythmic drug cibenzoline prolonged AFCL
, slow wave conduction velocity of atrial fibrillation, potential to reduce the proportion of abnormal atrial fibrillation. suggesting that the anti-arrhythmic drugs may increase the excitability of atrial fibrillation can be transferred between the period so that the AF to sinus rhythm.
current cardioversion of atrial fibrillation antiarrhythmic drug (AF ) of the mechanism is still not clear, studies suggest that anti-arrhythmic drugs by prolonging the atrial effective refractory period (ERP)
, thus increasing the wavelength of atrial atrial fibrillation (conduction velocity and effective refractory period t) and play a role [1 , 2]. but Wijffels, etc. [3
] found in the goat model of sustained atrial fibrillation, the atrial antiarrhythmic drug does not increase the wavelength, its antiarrhythmic effect is due to drugs prolong atrial excitable interval (EP ). This study was in February 2000 ~ 2001
in January in the goat model of persistent atrial fibrillation on the analysis of class Ic antiarrhythmic drug cibenzoline on atrial membrane unipolar atrial electrogram morphology, trying to fight against heart rhythm disorders of drug cardioversion of atrial fibrillation to be the mechanism.
1 Materials and methods
goat model of sustained atrial fibrillation model method and Wijffels et al [4] the same: seven female goats, weighing 49 ~ 61 kg after anesthesia left thoracotomy, the three electrodes with 83
the silicone suture on the atrial surface, five electrodes in the left atrial appendage, Bachmann's bundle in 14 and 4 in the right atrial appendage, 30 in the left atrial free wall, 30
were in the right atrial free wall. electrode spacing in the Bachmann bundle was 6 mm, other parts of the 4 mm. another four electrodes in the left ventricle to record ventricular suture signal, 3
a silver plate electrode in the subcutaneous ECG records can be independent of the electrode. closed chest, the electrode lead set by the subcutaneous tunnel outside the neck skin. After 2 weeks, the goat AF automatically connected vitro stimulation system. The system consists of a personal computer and a stimulator (
Medt ronicSP3084) form, the computer analysis of a pair of electrodes continuous atrial electrocardiogram, sinus rhythm will be given if it is found the rapid stimulation of 1 s (duration 2 ms, interval 20 ms, 4
times the diastolic threshold) to trigger atrial fibrillation. by the way of a continuous 24 h per day to maintain atrial fibrillation can be caused by 1 to 3 weeks of persistent AF (lasting more than 24 h). to be sustained AF to maintain 4
weeks after intravenous cibenzoline [0.1 mg / (kg • min)], until the termination of atrial fibrillation.
signal acquisition and analysis using ......< br> Source:
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